Title: Impact of large ovarian endometriomas on the response to superovulation for in vitro fertilization: a retrospective study
نویسندگان
چکیده
Objective: To assess the response to superovulation for in vitro fertilization (IVF) in patients with unilateral endometriomas with diameter ≥ 5 cm and in the contralateral healthy ovary. Study design: This retrospective analysis of a prospectively collected database included patients who underwent superovulation for IVF/ICSI cycles and had unoperated single unilateral endometrioma with diameter ≥ 5 cm and healthy contralateral ovary. The primary outcome of the study was to compare the number of oocyte retrieved in the ovary with the endometrioma and the contralateral healthy ovary. Results: The total number of follicles was lower in ovaries with endometriomas (2.6 ± 1.3) than in healthy ovaries (4.8 ± 2.0; p<0.001). The number of codominant follicles and the total number of oocytes retrieved were lower in ovaries with endometriomas (1.5 ± 0.9 and 2.0 ± 1.2) than in the contralateral ovaries (3.7 ± 1.5 and 4.2 ± 1.7; p<0.001, respectively). The number of oocytes retrieved suitable for fertilization was lower in ovaries with endometriomas (1.5±1.1) than in the healthy ovaries (3.3±1.5; p<0.001). The total number of oocytes retrieved and the number of oocytes retrieved suitable for fertilization were lower in ovaries with endometriomas respectively in 21 (80.8%) and in 20 (76.9%) cases. The decreased responsiveness to ovarian superovulation was confirmed considering women with ultrasonographic diagnosis of deep infiltrating endometriosis. 30.8% of patients had positive HCG; the pregnancy rate was 23.1%. Conclusion: The presence of large endometriomas (≥ 5 cm) at time of IVF significantly decreases the number of oocyte retrieved compared with the contralateral healthy ovaries. 3
منابع مشابه
Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles
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